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The
Rashkovan Lab
CHU Sainte-Justine Research Center

About Us

The Rashkovan Lab, established in 2023, is based at the CHU Sainte-Justine Research Center in Montreal, Canada. We are focused on dissecting the metabolic circuitries involved in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) using primary patient samples, patient-derived xenografts, and mouse models. 

Lab news

September 2024

July 2024

June 2024

May 2024

April 2024

January 2024

September 2023

May 2023

April 2023 

January 2023

Juliette becomes the lab's first PhD student!

The lab receives funding from the Cancer Research Society!

Juliette is awarded an excellence fellowship from the Sainte-Justine Foundation! Eléonore is awarded a recruitment fellowship from the Sainte-Justine Foundation!

Céline Estephan joins the lab as a summer student!

Juliette wins a poster prize at the Pathologie and Biologie Cellulaire Research Day!

Maxine Selye and Eléonore Provencher are the lab's newest Master's students!

Juliette Durocher joins the lab as a Master's student!

Hao Yang joins the lab as a Research Associate!

Welcome to the Lab's first summer students, Juliette Durocher & Allison Sy!

The lab is awarded the Cole Foundation Transition Award!

The Rashkovan Lab is open and hiring!

Selected Publications

Gower M, Li X, Aguilar-Navarro AG, Lin B, Fernandez M, Edun G, Nader M, Rondeau V, Arruda A, Tierens A, Eames Seffernick A, Pölönen P, Durocher J, Wagenblast E, Yang L, Lee HS, Mullighan CG, Teachey D, Rashkovan M, Tremblay CS, Herranz D, Itkin T, Loghavi S, Dick JE, Schwartz G, Perusini MA, Sibai H, Hitzler J, Gruber TA, Minden M, Jones CL, Dolgalev I, Jahangiri S, Tikhonova AN. An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup. Sci Transl Med. 2025 Jan;17(779):eadr2012. doi: 10.1126/scitranslmed.adr2012. Epub 2025 Jan 1. PMID: 39742502
​​​​​​Rashkovan M, Albero R, Gianni F, Perez-Duran P, Miller HI, Mackey AL, Paietta EM, Tallman MS, Rowe JM, Litzow MR, Wiernik PH, Luger S, Sulis ML, Soni RK, Ferrando AA. Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia. Cancer Discovery. 2022 Mar 1;12(3):856-871. doi: 10.1158/2159-8290.CD-21-0551. PMID: 34711640; PMCID: PMC8904296.
Montefiori L, Bendig S, Gu Z, Chen X, Polonen P, Ma X, Murison A, Zeng A, Garcia-Prat L, Dickerson K, Iacobucci I, Abdelhamed S, Hiltenbrand R, Mead PE, Mehr CM, Xu B, Cheng Z, Chang TC, Westover T, Ma J, Stengel A, Kimura S, Qu C, Valentine MB, Rashkovan M, Luger S, Litzow MR, Rowe JM, Den Boer ML, Wang V, Yin J, Kornblau SM, Hunger SP, Loh ML, Pui CH, Yang W, Crews KR, Roberts KG, Yang JJ, Relling MV, Evans WE, Stock W, Paietta EM, Ferrando AA, Zhang J, Kern W, Haferlach T, Wu G, Dick JE, Klco JM, Haferlach C, Mullighan CG. Enhancer hijacking drives oncogenic BCL11B expression in lineage ambiguous stem cell leukemia. Cancer Discovery. 2021 Jun 8;candisc.0145.2021. doi: 10.1158/2159-8290.CD-21-0145.
Belver L, Yang AY, Albero R, Herranz D, Brundu FG, Quinn SA, Perez-Duran P, Alvarez S, Gianni F, Rashkovan M, Gurung D, Rocha PP, Raviram R, Reglero C, Cortes JR, Cooke AJ, Wendorff AA, Cordo V, Meijerink JP, Rabadan R and Ferrando AA (2019). Gata3-controlled nucleosome eviction drives Myc enhancer activity in T-cell development and leukemia. Cancer Discovery. 2019;9(12):1774‐1791.
Rashkovan M and Ferrando AA (2019). Metabolic dependencies and vulnerabilities in leukemia. Genes and Development. 33.
Ross J*, Rashkovan M*, Fraszczak J, Joly Beauparlant C, Vadnais C, Winkler R, Droit A, Kosan C, Möröy T (2019). Deletion of the Miz-1 POZ domain increases efficacy of cytarabine treatment in T- and B-ALL/lymphoma mouse models. Cancer Research. August 15 2019 (79) (16) 4184-4195.
Wendorff AA, Quinn SA, Rashkovan M, Madubata CJ, Ambesi-Impiombato A, Litzow MR, Tallman MS, Paietta E, Paganin M, Basso G, Gastier-Foster JM, Loh ML, Rabadan R, Van Vlierberghe P, Ferrando AA (2019). Phf6 loss enhances HSC self-renewal driving tumor initiation and leukemia stem cell activity in T-ALL. Cancer Discovery. Mar;9(3):436-451.
Rashkovan M, Vadnais C, Ross J, Gigoux M, Suh WK, Gu W, Kosan C, and Möröy T (2014). Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination. Proc. Natl. Acad. Sci. USA. 111(50): E5411-E5419
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