Rashkovan Lab
.jpg)
The
Rashkovan Lab
CHU Sainte-Justine Research Center
About Us
The Rashkovan Lab, established in 2023, is based at the CHU Sainte-Justine Research Center in Montreal, Canada. We are focused on dissecting the metabolic circuitries involved in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) using primary patient samples, patient-derived xenografts, and mouse models.
Lab news
July 2024
June 2024
May 2024
April 2024
January 2024
September 2023
May 2023
April 2023
January 2023
The lab receives funding from the Cancer Research Society!
Juliette is awarded an excellence fellowship from the Sainte-Justine Foundation! Eléonore is awarded a recruitment fellowship from the Sainte-Justine Foundation!
Céline Estephan joins the lab as a summer student!
Juliette wins a poster prize at the Pathologie and Biologie Cellulaire Research Day!
Maxine Selye and Eléonore Provencher are the lab's newest Master's students!
Juliette Durocher joins the lab as a Master's student!
Hao Yang joins the lab as a Research Associate!
Welcome to the Lab's first summer students, Juliette Durocher & Allison Sy!
The lab is awarded the Cole Foundation Transition Award!
The Rashkovan Lab is open and hiring!
Selected Publications
Rashkovan M, Albero R, Gianni F, Perez-Duran P, Miller HI, Mackey AL, Paietta EM, Tallman MS, Rowe JM, Litzow MR, Wiernik PH, Luger S, Sulis ML, Soni RK, Ferrando AA. Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia. Cancer Discovery. 2022 Mar 1;12(3):856-871. doi: 10.1158/2159-8290.CD-21-0551. PMID: 34711640; PMCID: PMC8904296.
Montefiori L, Bendig S, Gu Z, Chen X, Polonen P, Ma X, Murison A, Zeng A, Garcia-Prat L, Dickerson K, Iacobucci I, Abdelhamed S, Hiltenbrand R, Mead PE, Mehr CM, Xu B, Cheng Z, Chang TC, Westover T, Ma J, Stengel A, Kimura S, Qu C, Valentine MB, Rashkovan M, Luger S, Litzow MR, Rowe JM, Den Boer ML, Wang V, Yin J, Kornblau SM, Hunger SP, Loh ML, Pui CH, Yang W, Crews KR, Roberts KG, Yang JJ, Relling MV, Evans WE, Stock W, Paietta EM, Ferrando AA, Zhang J, Kern W, Haferlach T, Wu G, Dick JE, Klco JM, Haferlach C, Mullighan CG. Enhancer hijacking drives oncogenic BCL11B expression in lineage ambiguous stem cell leukemia. Cancer Discovery. 2021 Jun 8;candisc.0145.2021. doi: 10.1158/2159-8290.CD-21-0145.
Belver L, Yang AY, Albero R, Herranz D, Brundu FG, Quinn SA, Perez-Duran P, Alvarez S, Gianni F, Rashkovan M, Gurung D, Rocha PP, Raviram R, Reglero C, Cortes JR, Cooke AJ, Wendorff AA, Cordo V, Meijerink JP, Rabadan R and Ferrando AA (2019). Gata3-controlled nucleosome eviction drives Myc enhancer activity in T-cell development and leukemia. Cancer Discovery. 2019;9(12):1774‐1791.